GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs7692995 | 1 | rs10446630 | chr4:17958690 | NCAPG | chr4:17812525-17846485:+ | 0.09 | 4.2 | 2.91E-5 | Height |
| BRCA | cis | rs4660306 | 1 | rs1044717 | chr1:45976587 | CCDC163P | chr1:45960581-45965646:- | -0.82 | -27.58 | 7.41E-127 | Homocysteine levels |
| BRCA | cis | rs4660306 | 1 | rs1044717 | chr1:45976587 | MMACHC | chr1:45965856-45976737:+ | -0.14 | -3.94 | 8.83E-5 | Homocysteine levels |
| BRCA | cis | rs10448080 | 1 | rs10448080 | chr8:28604791 | CCDC25 | chr8:27590835-27630170:- | 0.14 | 3.63 | 0.000294 | Height |
| BRCA | cis | rs10448080 | 1 | rs10448080 | chr8:28604791 | ELP3 | chr8:27947749-28048667:+ | 0.18 | 4.6 | 4.67E-6 | Height |
| BRCA | cis | rs10448080 | 1 | rs10448080 | chr8:28604791 | EXTL3 | chr8:28559153-28611202:+ | 0.13 | 3.68 | 0.000249 | Height |
| BRCA | cis | rs10448080 | 1 | rs10448080 | chr8:28604791 | FBXO16 | chr8:28285930-28347784:- | 0.13 | 3.58 | 0.000353 | Height |
| BRCA | cis | rs10448080 | 1 | rs10448080 | chr8:28604791 | INTS9 | chr8:28625180-28747698:- | 0.16 | 4.2 | 2.93E-5 | Height |
| BRCA | cis | rs10448080 | 1 | rs10448080 | chr8:28604791 | ZNF395 | chr8:28203104-28347784:- | 0.13 | 4.11 | 4.22E-5 | Height |
| BRCA | cis | rs10160456 | 1 | rs10450561 | chr11:27309956 | LGR4 | chr11:27387510-27494334:- | -0.14 | -4.09 | 4.69E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10160456 | 1 | rs10450562 | chr11:27310006 | LGR4 | chr11:27387510-27494334:- | 0.14 | 4.09 | 4.59E-5 | Bone mineral density (paediatric, skull) |
| BRCA | cis | rs10454142 | 1 | rs10454142 | chr2:48646399 | GTF2A1L | chr2:48844948-48960284:+ | -0.22 | -5.36 | 1.03E-7 | Sex hormone-binding globulin levels |
| BRCA | cis | rs10454142 | 1 | rs10454142 | chr2:48646399 | KLRAQ1 | chr2:48667908-48742524:+ | 0.2 | 4.9 | 1.11E-6 | Sex hormone-binding globulin levels |
| BRCA | cis | rs10454142 | 1 | rs10454142 | chr2:48646399 | STON1-GTF2A1L | chr2:48796159-48906746:+ | -0.22 | -6.17 | 9.44E-10 | Sex hormone-binding globulin levels |
| BRCA | cis | rs1577917 | 1 | rs10455158 | chr6:86672825 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -17.96 | 3.15E-63 | Response to antipsychotic treatment |